DIFFERENTIAL-EFFECTS OF CALCIUM-CHANNEL ANTAGONISTS ON TITYUSTOXIN AND OUABAIN-INDUCED RELEASE OF [H-3] ACETYLCHOLINE FROM BRAIN CORTICAL SLICES

被引：22

作者：

CASALI, TAA

GOMEZ, RS

MORAESSANTOS, T

GOMEZ, MV

机构：

[1] UFMG BELO,ICB,DEPT FARMACOL,GERAIS,BRAZIL

[2] UFMG BELO,FAC MED,DEPT CIRURG,GERAIS,BRAZIL

[3] UFMG BELO,FAC FARM,DEPT ALIMENTOS,GERAIS,BRAZIL

来源：

NEUROPHARMACOLOGY | 1995年 / 34卷 / 06期

关键词：

TITYUSTOXIN; OUABAIN; CALCIUM CHANNEL ANTAGONISTS; ACETYLCHOLINE OMEGA-CONOTOXINS; OMEGA-CONOTOXIN MVIIC; OMEGA-AGAIVA;

D O I：

10.1016/0028-3908(95)00019-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this paper, the effect of calcium channel blockers on acetylcholine release induced by tityustoxin and ouabain in rat brain cortical slices is described. Cadmium, a non-specific blocker of calcium channels, inhibited the release of ACh induced by tityustoxin. L-type calcium channel blockers (verapamil, nifedipine and diltiazen) had no effect on the release of ACh induced by tityustoxin. The release of ACh was also unaffected by nickel, a T-type calcium channel blocker, and the conotoxins GVIA and MVIIC, blockers of N and Q-type calcium channels. Agatoxin IVA, a specific blocker of the P-type calcium channel, inhibited the release of ACh induced by tityustoxin by 50%. The spontaneous release of ACh as well as ouabain-induced release of ACh was unaffected by any of the calcium channel blockers studied. It is concluded that ACh release induced by tityustoxin is mediated by Ca2+ influx via P-type calcium channels.

引用

页码：599 / 603

页数：5

共 29 条

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