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THE PHARMACOKINETICS OF CEFUROXIME AXETIL IN THE SICK ELDERLY PATIENT
被引:14
作者:
RIDGWAY, E
STEWART, K
RAI, G
KELSEY, MC
BIELAWSKA, C
机构:
[1] WHITTINGTON HOSP,DEPT MICROBIOL,LONDON N19 5NF,ENGLAND
[2] WHITTINGTON HOSP,DEPT GERIATR MED,LONDON N19 5NF,ENGLAND
关键词:
D O I:
10.1093/jac/27.5.663
中图分类号:
R51 [传染病];
学科分类号:
100401 ;
摘要:
The pharmacokinetics of cefuroxime axetil (RS3 formulation) were studied in 20 elderly patients following admission for lower respiratory or urinary tract infection. The mean age was 83·9 years. A 12-hourly dose of 250 mg was given for five days. The mean time to attain maximum serum concentration was 3.2 h with a mean peak concentration of 8·5 mg/1. The mean serum elimination half-life was 3.5 h and the AUC0-∞p 60.4 mg/h.l. There was no accumulation of the drug in the patients studied after five days treatment. The data suggest that the standard dosage regimen is adequate in the sick elderly patient. © 1991 The British Society for Antimicrobial Chemotherapy.
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页码:663 / 668
页数:6
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