MOLECULAR TARGET SIZE OF THE VANILLOID (CAPSAICIN) RECEPTOR IN PIG DORSAL-ROOT GANGLIA

被引：34

作者：

SZALLASI, A

BLUMBERG, PM

机构：

[1] Molecular Mechanisms of Tumor Promotion Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda

来源：

LIFE SCIENCES | 1991年 / 48卷 / 19期

关键词：

D O I：

10.1016/0024-3205(91)90242-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The size of the vanilloid receptor was examined by high-energy radiation inactivation analysis of the binding of [H-3]resiniferatoxin to pig dorsal root ganglion membranes; it was found to be 270 +/- 25 kDa. This value most likely represents the size of a receptor complex rather than of an individual subunit. Other ligand-gated cation channel complexes have reported molecular weights in this range, e.g. 300 kDa for the acetylcholine receptor.

引用

页码：1863 / 1869

页数：7