SOME METABOLIC RELATIONSHIPS BETWEEN BIOPTERIN AND FOLATE - IMPLICATIONS FOR THE METHYL TRAP HYPOTHESIS

被引：74

作者：

KAUFMAN, S

机构：

[1] Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, 20892, Maryland, 9000 Rockville Pike, Building 36

来源：

NEUROCHEMICAL RESEARCH | 1991年 / 16卷 / 09期

关键词：

TETRAHYDROBIOPTERIN; METHYL TRAP HYPOTHESIS; METHYL TETRAHYDROFOLATE; METHYLENE TETRAHYDROFOLATE REDUCTASE; VITAMIN-B12;

D O I：

10.1007/BF00965847

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tetrahydrobiopterin and the folate coenzymes can reciprocally interact in ways that would be useful to the metabolic pathways subserved by both of these coenzymes. Thus, through one of the reactions catalyzed by methylene tetrahydrofolate reductase, 5-CH3-H-4-folate can regenerate BH4 from q-BH2 and qBH4 can provide an escape from the "methyl trap."

引用

页码：1031 / 1036

页数：6

共 40 条

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