STUDIES ON INTERLEUKIN-2 RECEPTOR EXPRESSION AND IL-2 PRODUCTION BY MURINE T-CELL LYMPHOMAS

被引：21

作者：

DIAMANTSTEIN, T ^{[1
]}

OSAWA, H ^{[1
]}

GRAF, L ^{[1
]}

SCHIRRMACHER, V ^{[1
]}

机构：

[1] DEUTSCH KREBSFORSCHUNGSZENTRUM, INST IMMUNOL & GENET, D-6900 HEIDELBERG, GERMANY

来源：

BRITISH JOURNAL OF CANCER | 1985年 / 51卷 / 01期

关键词：

D O I：

10.1038/bjc.1985.4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In order to study the possible role of the T-lymphocyte growth factor. Interleukin 2 (IL 2), and/or of the IL-2 receptor in the autonomous growth of leukemic cells. Mouse cell lines (15) of various etiology were analyzed for IL-2 receptor expression and for the capacity to secrete IL-2. Several but not all of the cell lines tested were IL-2 receptor positive. The cells constitutively expressing IL-2 receptors at their surface could not be stimulated IL-2. Cell producing and secreting IL-2 did not express detectable amounts of IL-2 receptors at their surface. Proliferation of the leukemic cells was independent of exogenous IL-2. The monoclonal anti-IL-2 receptor antibody AMT-13 inhibited IL-2 dependent proliferation of activated normal T-lymphocytes but failed to inhibit the growth of IL-2 receptor expressing leukemia cells. The results argue against the autocrine stimulation hypothesis but do not exclude the possibility of involvement of functionally altered IL-2 receptors on autonomous cell growth.

引用

页码：23 / 30

页数：8