AMIDES AS A NEW-TYPE OF BACKBONE MODIFICATION IN OLIGONUCLEOTIDES

被引：119

作者：

DEMESMAEKER, A ^{[1
]}

WALDNER, A ^{[1
]}

LEBRETON, J ^{[1
]}

HOFFMANN, P ^{[1
]}

FRITSCH, V ^{[1
]}

WOLF, RM ^{[1
]}

FREIER, SM ^{[1
]}

机构：

[1] ISIS PHARMACEUT,CARLSBAD,CA 92008

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1994年 / 33卷 / 02期

关键词：

D O I：

10.1002/anie.199402261

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

No decrease in the affinity for the complementary RNA target is observed when the natural phosphodiester linkages in oligonucleotides are replaced with amide units. This was found in investigations of oligonucleotides containing one or more modified components 1. In addition these oligonucleotides are roughly ten times more resistant towards 3′‐exonucleases. (Figure Presented.) Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：226 / 229

页数：4

共 29 条

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