A NOVEL THIOETHER LINKER - CHEMICAL SYNTHESIS OF A HIV-1 PROTEASE ANALOG BY THIOETHER LIGATION

被引：46

作者：

ENGLEBRETSEN, DR ^{[1
]}

GARNHAM, BG ^{[1
]}

BERGMAN, DA ^{[1
]}

ALEWOOD, PF ^{[1
]}

机构：

[1] UNIV QUEENSLAND,CTR DRUG DESIGN & DEV,BRISBANE,QLD 4072,AUSTRALIA

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 48期

关键词：

D O I：

10.1016/0040-4039(95)01843-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using the novel thioether linker 4-[N-Boc-2-aminoethylmercapto] methyl phenoxyacetic acid, peptides bearing a C-terminal thiol functionality were synthesised; Reaction of the thiol functionalised peptide with an N-terminal bromoacetylated peptide led to ligation of the two peptides via a thioether bond. The strategy was used to synthesise an enzymatically active analogue of HIV-1 Protease.

引用

页码：8871 / 8874

页数：4

共 19 条

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