3-DEAZAPURINES AND 7-DEAZAPURINES - DUPLEX STABILITY OF OLIGONUCLEOTIDES CONTAINING MODIFIED ADENINE OR GUANINE BASES

被引：27

作者：

GREIN, T ^{[1
]}

LAMPE, S ^{[1
]}

MERSMANN, K ^{[1
]}

ROSEMEYER, H ^{[1
]}

THOMAS, H ^{[1
]}

SEELA, F ^{[1
]}

机构：

[1] UNIV OSNABRUCK,INST CHEM,ORGAN & BIOORGAN CHEM LAB,D-49069 OSNABRUCK,GERMANY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(01)80665-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Oligonucleotide duplexes were destabilized when the purine bases of 2'-deoxyadenosine or 2'-deoxyguanosine were replaced by the corresponding 3-deazapurine (imidazo[4,5-c]pyridine) or 7-deazapurine (pyrrolo[2,3-d]pyrimidine) derivatives. Only d(AT)(6) was stabilized by incorporation of c A when high salt condition were used. The stability of deazapurine base-protecting groups was also investigated.

引用

页码：971 / 976

页数：6

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