DEOXYOLIGONUCLEOTIDES CONTAINING 2',5' ACETAL LINKAGES - SYNTHESIS AND HYBRIDIZATION PROPERTIES

被引：15

作者：

PUDLO, JS ^{[1
]}

CAO, XD ^{[1
]}

SWAMINATHAN, S ^{[1
]}

MATTEUCCI, MD ^{[1
]}

机构：

[1] GILEAD SCI INC, FOSTER CITY, CA 94404 USA

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(00)78530-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two 3'-deoxy-5-methyluridine-3'-deoxy-5-methyluridine dimers interconnected by 2',5' formacetal 3 and thioformacetal 4 were synthesized and incorporated into oligonucleotides. The 2',5' thioformacetal derivative resulted in substantial destabilization of duplex formation with ssRNA and ssDNA, the 2',5' formacetal ODN resulted in only modest destabilization of ssDNA and ssRNA as compared to the control 3',5' phosphodiester.

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页码：9315 / 9318

页数：4

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