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MAN-MADE ANTIBODIES

被引：825
作者：
WINTER, G
MILSTEIN, C
机构：
[1] MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, Hills Road
来源：
NATURE | 1991年 / 349卷 / 6307期
关键词：
D O I：
10.1038/349293a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Monoclonal antibodies can now be genetically engineered and endowed with new properties. In the future, gene technology could enable antigen-binding fragments to be made by exploiting repertoires of variable domain genes derived from immunized animals and expressed in bacteria. How readily can this approach be extended to production of 'in vitro' repertoires of variable domain genes, and obviate the immunization of animals?
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页码：293 / 299
页数：7
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