HEPATITIS-B VIRUS - SIGNIFICANCE OF NATURALLY-OCCURRING MUTANTS

被引:36
作者
BLUM, HE
机构
[1] Medical Clinic B, Department of Internal Medicine, University of Zürich
关键词
HEPATITIS-B VIRUS; LIVER DISEASE; VIRAL MUTANTS; QUASI-SPECIES; DNA SEQUENCING; POLYMERASE CHAIN REACTION; VACCINE ESCAPE; DIAGNOSTIC ESCAPE;
D O I
10.1159/000150294
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Mutations of viral genomes are normal biological events and result in the coexistence of viral genotypes in infected individuals ('quasispecies'). Hepatitis B virus (HBV) and the related animal hepadnaviruses have a mutation rate which is intermediate between DNA and RNA viruses because they replicate asymmetrically via reverse transcription of an RNA intermediate. HBV mutants affecting all known reading frames of the viral genome have been demonstrated in patients with acute fulminant or chronic HBV infection. Some of the mutations identified to date suggest a contribution to viral latency, low level HBV infection, the severity of liver disease and vaccine escape. Since most viral genomes carry more than one mutation and most individuals are infected by more than one variant, the demonstration of a causal relationship between a single mutation and a biological or pathobiological effect requires the in vitro and in vivo analysis of genetically defined mutants. Such analyses should allow a molecular understanding of the genetic contribution of HBV to the variable natural course of HBV infection, ranging from an asymptomatic healthy carrier state to acute or even fulminant hepatitis, chronic liver disease, liver cirrhosis and hepatocellular carcinoma.
引用
收藏
页码:40 / 50
页数:11
相关论文
共 89 条
  • [41] IDENTIFICATION AND CHARACTERIZATION OF INTRAHEPATIC HEPATITIS-B VIRUS-DNA IN HBSAG-SERONEGATIVE PATIENTS WITH CHRONIC LIVER-DISEASE AND HEPATOCELLULAR-CARCINOMA IN TAIWAN
    LAI, MY
    CHEN, PJ
    YANG, PM
    SHEU, JC
    SUNG, JL
    CHEN, DS
    [J]. HEPATOLOGY, 1990, 12 (03) : 575 - 581
  • [42] HETEROGENEITY OF AUSTRALIA ANTIGEN
    LEBOUVIER, GL
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1971, 123 (06) : 671 - +
  • [43] A HEPATITIS-B VIRUS MUTANT ASSOCIATED WITH AN EPIDEMIC OF FULMINANT-HEPATITIS
    LIANG, TJ
    HASEGAWA, K
    RIMON, N
    WANDS, JR
    BENPORATH, E
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (24) : 1705 - 1709
  • [44] HEPATITIS-B VIRUS-INFECTION IN PATIENTS WITH IDIOPATHIC LIVER-DISEASE
    LIANG, TJ
    BARUCH, Y
    BENPORATH, E
    ENAT, R
    BASSAN, L
    BROWN, NV
    RIMON, N
    BLUM, HE
    WANDS, JR
    [J]. HEPATOLOGY, 1991, 13 (06) : 1044 - 1051
  • [45] CHARACTERIZATION AND BIOLOGICAL PROPERTIES OF A HEPATITIS-B VIRUS ISOLATED FROM A PATIENT WITHOUT HEPATITIS-B VIRUS SEROLOGIC MARKERS
    LIANG, TJ
    BLUM, HE
    WANDS, JR
    [J]. HEPATOLOGY, 1990, 12 (02) : 204 - 212
  • [46] LIANG TJ, 1989, J CLIN INVEST, V84, P2367
  • [47] SEQUENCE OF A REPLICATION COMPETENT HEPATITIS-B VIRUS GENOME WITH A PREX OPEN READING FRAME
    LONCAREVIC, IF
    ZENTGRAF, H
    SCHRODER, CH
    [J]. NUCLEIC ACIDS RESEARCH, 1990, 18 (16) : 4940 - 4940
  • [48] A VIRUS IN BEECHEY GROUND-SQUIRRELS THAT IS RELATED TO HEPATITIS-B VIRUS OF HUMANS
    MARION, PL
    OSHIRO, LS
    REGNERY, DC
    SCULLARD, GH
    ROBINSON, WS
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (05): : 2941 - 2945
  • [49] VIRUS OF PEKIN DUCKS WITH STRUCTURAL AND BIOLOGICAL RELATEDNESS TO HUMAN HEPATITIS-B VIRUS
    MASON, WS
    SEAL, G
    SUMMERS, J
    [J]. JOURNAL OF VIROLOGY, 1980, 36 (03) : 829 - 836
  • [50] GENETIC ALTERATIONS IN THE GENE ENCODING THE MAJOR HBSAG - DNA AND IMMUNOLOGICAL ANALYSIS OF RECURRENT HBSAG DERIVED FROM MONOCLONAL ANTIBODY-TREATED LIVER-TRANSPLANT PATIENTS
    MCMAHON, G
    EHRLICH, PH
    MOUSTAFA, ZA
    MCCARTHY, LA
    DOTTAVIO, D
    TOLPIN, MD
    NADLER, PI
    OSTBERG, L
    [J]. HEPATOLOGY, 1992, 15 (05) : 757 - 766