KERATOCONUS CORNEAS - INCREASED GELATINOLYTIC ACTIVITY APPEARS AFTER MODIFICATION OF INHIBITORS

被引：64

作者：

BROWN, D

CHWA, MM

OPBROEK, A

KENNEY, MC

机构：

[1] Ophthalmology Research Laboratories, Department of Surgery, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, UCLA Medical School Affiliate, Los Angeles, CA 90048, 8700 Beverly Boulevard, Halper Building

来源：

CURRENT EYE RESEARCH | 1993年 / 12卷 / 06期

关键词：

D O I：

10.3109/02713689309001835

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

We examined the metalloproteinase activity from normal and keratoconus corneal extracts. No differences were detected in the total amount of the metalloproteinase or its physical form of activation. However, there was a significant elevation in enzymatic activity in the keratoconus extracts after chemical modification of inhibitory elements. This suggests either a difference in the enzymatic capabilities of keratoconus corneas or, as suggested previously, a decrease in the amount of TIMP (tissue inhibitor of metalloproteinase) present in the tissue.

引用

页码：571 / 581

页数：11

共 28 条

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