GALANIN ANTAGONISTS BLOCK GALANIN-INDUCED FEEDING IN THE HYPOTHALAMUS AND AMYGDALA OF THE RAT

被引：121

作者：

CORWIN, RL

ROBINSON, JK

CRAWLEY, JN

机构：

[1] Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, Maryland, 20892, Building 10

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 1993年 / 5卷 / 11期

关键词：

ANTAGONISTS; CENTRAL NUCLEUS OF THE AMYGDALA; FOOD CONSUMPTION; NEUROPEPTIDE; PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS; RECEPTOR;

D O I：

10.1111/j.1460-9568.1993.tb00221.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Galanin significantly increased food intake when microinjected into the region of the central nucleus of the amygdala as well as into the paraventricular nucleus of the hypothalamus. In the amygdala this effect was specific to feeding; no change in grooming, resting, or other behaviour was observed after galanin treatment. These results provide evidence that the amygdala may be an important site in the mediation of galanin-induced feeding. The galanin receptor antagonists, C7 and M40, antagonized galanin-induced feeding, while having no effect alone on food consumption in free-feeding rats. These new galanin receptor antagonists provide useful tools for further investigating the role of endogenous galanin in the regulation of feeding.

引用

页码：1528 / 1533

页数：6

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