STABLE ASSOCIATION BETWEEN THE BOVINE PAPILLOMAVIRUS-E5 TRANSFORMING PROTEIN AND ACTIVATED PLATELET-DERIVED GROWTH-FACTOR RECEPTOR IN TRANSFORMED MOUSE CELLS

被引：115

作者：

PETTI, L ^{[1
]}

DIMAIO, D ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,DEPT GENET,333 CEDAR ST,NEW HAVEN,CT 06510

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 15期

关键词：

D O I：

10.1073/pnas.89.15.6736

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The 44-amino acid E5 transforming protein of bovine papillomavirus is the shortest protein known to induce tumorigenic transformation of fibroblasts. We showed previously that expression of the E5 protein activates the cellular beta-receptor for platelet-derived growth factor (PDGF) and proposed that the activated receptor transmits the transforming signal to the cell. Here we use coimmunoprecipitation analysis to show that the E5 protein and the activated PDGF receptor exist in a stable complex in transformed mouse C127 cells. These results suggest a distinct mechanism of growth factor receptor activation and provide further evidence that the PDGF receptor is an important target of the E5 protein.

引用

页码：6736 / 6740

页数：5

共 34 条

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