ANTIINFLAMMATORY, ANALGESIC AND ANTIPYRETIC N-ACETYL-DELTA-2-PYRAZOLINES AND DIHYDROTHIENOCOUMARINES

被引：76

作者：

MANNA, F ^{[1
]}

CHIMENTI, F ^{[1
]}

BOLASCO, A ^{[1
]}

CENICOLA, ML ^{[1
]}

DAMICO, M ^{[1
]}

PARRILLO, C ^{[1
]}

ROSSI, F ^{[1
]}

MARMO, E ^{[1
]}

机构：

[1] NAPLES UNIV,FAC MED & SURG 1,INST PHARMACOL & TOXICOL,I-80138 NAPLES,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 27卷 / 06期

关键词：

ANTIINFLAMMATORY (ACTIVITY); ANALGESIC (ACTIVITY); ANTIPYRETIC (ACTIVITY); N-ACETYL-3,5-DIARYL-DELTA-2-PYRAZOLINES (SYNTHESIS); 2-ARYL-DIHYDROTHIENOCOUMARINES (SYNTHESIS);

D O I：

10.1016/0223-5234(92)90142-N

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1-Acetyl-3-(2-hydroxyphenyl)-5-(RR'-aryl)-4,5-dihydro-(1H)pyrazoles (2a-o) were synthesized and showed anti-inflammatory and analgesic activity. The substituents on the 5-aryl group were necessary for biological activity. R-R'-aryl-2-dihydro-1,2(4H)thieno(2,3-c)benzo(e)pyranone-4 derivatives (3a-f) also showed analgesic and anti-inflammatory activity. The position and the number of the substituents caused a modulation of analgesic or anti-inflammatory activity of the N-acetyl-DELTA2-pyrazoline 2 and dihydrothienocoumarines 3. All compounds showed low antipyretic activity.

引用

页码：633 / 639

页数：7

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