ANTIINFLAMMATORY, ANALGESIC AND ANTIPYRETIC N-ACETYL-DELTA-2-PYRAZOLINES AND DIHYDROTHIENOCOUMARINES

被引：76

作者：

MANNA, F ^{[1
]}

CHIMENTI, F ^{[1
]}

BOLASCO, A ^{[1
]}

CENICOLA, ML ^{[1
]}

DAMICO, M ^{[1
]}

PARRILLO, C ^{[1
]}

ROSSI, F ^{[1
]}

MARMO, E ^{[1
]}

机构：

[1] NAPLES UNIV,FAC MED & SURG 1,INST PHARMACOL & TOXICOL,I-80138 NAPLES,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 27卷 / 06期

关键词：

ANTIINFLAMMATORY (ACTIVITY); ANALGESIC (ACTIVITY); ANTIPYRETIC (ACTIVITY); N-ACETYL-3,5-DIARYL-DELTA-2-PYRAZOLINES (SYNTHESIS); 2-ARYL-DIHYDROTHIENOCOUMARINES (SYNTHESIS);

D O I：

10.1016/0223-5234(92)90142-N

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1-Acetyl-3-(2-hydroxyphenyl)-5-(RR'-aryl)-4,5-dihydro-(1H)pyrazoles (2a-o) were synthesized and showed anti-inflammatory and analgesic activity. The substituents on the 5-aryl group were necessary for biological activity. R-R'-aryl-2-dihydro-1,2(4H)thieno(2,3-c)benzo(e)pyranone-4 derivatives (3a-f) also showed analgesic and anti-inflammatory activity. The position and the number of the substituents caused a modulation of analgesic or anti-inflammatory activity of the N-acetyl-DELTA2-pyrazoline 2 and dihydrothienocoumarines 3. All compounds showed low antipyretic activity.

引用

页码：633 / 639

页数：7

共 20 条

[11] MAKISUMI Y, 1975, CHEM ABSTR 164152R, V83
[12] MAKISUMI Y, 1975, CHEM ABSTR 111283Z, V83
[13] MAKISUMI Y, 1975, CHEM ABSTR 164153S, V83
[14] SOME NEW PHENOLIC PYRAZOLES FROM 2'-HYDROXYCHALCONES
OLUWADIYA, JO
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1981, 18 (07) : 1293 - 1295
[15] ANTICONVULSANT ACTIVITY AND MONOAMINE-OXIDASE INHIBITORY PROPERTIES OF 1,3,5-TRISUBSTITUTED PYRAZOLINES
PARMAR, SS
PANDEY, BR
DWIVEDI, C
HARBISON, RD
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1974, 63 (07) : 1152 - 1155
[16] Sallai J, 1976, ACTA PHARM HUNG, V46, P49
[17] Sangwan N.K., 1983, CHIMICA ACTA TURCICA, V11, P65
[18] ELECTROCHEMICAL SYNTHESIS OF HETEROCYCLIC-COMPOUNDS .18. ANODIC-OXIDATION OF 2'-HYDROXYCHALCONES
SANICANIN, Z
TABAKOVIC, I
[J]. ELECTROCHIMICA ACTA, 1988, 33 (11) : 1595 - 1600
[19] THAKARE VG, 1986, INDIAN J CHEM B, V25, P610
[20] XICLUNA A, 1979, EUR J MED CHEM, V14, P523

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