THE PHYSIOLOGICAL-ROLE OF NITRIC-OXIDE

被引:497
作者
BUTLER, AR [1 ]
WILLIAMS, DLH [1 ]
机构
[1] UNIV DURHAM,DEPT CHEM,DURHAM DH1 3LE,ENGLAND
关键词
D O I
10.1039/cs9932200233
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In the last six years it has become apparent that nitric oxide (NO) has a crucial and extensive role in human physiology. It acts as a messenger molecule effecting muscle relaxation, as a cytotoxic agent in the non-specific immune system, as a carcinogen, and as a neurotransmitter in the brain and peripheral nervous system. This article explores some of the chemistry of NO in an attempt to understand how such a modest molecule can play so many diverse roles.
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收藏
页码:233 / 241
页数:9
相关论文
共 55 条
  • [41] DECOMPOSITION OF ADDUCTS OF DIETHYLAMINE AND ISOPROPYLAMINE WITH NITROGEN(2) OXIDE
    RAGSDALE, RO
    KARSTETT.BR
    DRAGO, RS
    [J]. INORGANIC CHEMISTRY, 1965, 4 (03) : 420 - &
  • [42] Richter-Addo G.-B., 1992, METAL NITROSYLS
  • [43] KILLING OF PLASMODIUM-FALCIPARUM INVITRO BY NITRIC-OXIDE DERIVATIVES
    ROCKETT, KA
    AWBURN, MM
    COWDEN, WB
    CLARK, IA
    [J]. INFECTION AND IMMUNITY, 1991, 59 (09) : 3280 - 3283
  • [44] FLOW-INDUCED RELEASE OF ENDOTHELIUM-DERIVED RELAXING FACTOR
    RUBANYI, GM
    ROMERO, JC
    VANHOUTTE, PM
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 250 (06): : 1145 - 1149
  • [45] HUMAN-NEUTROPHILS AND MONONUCLEAR-CELLS INHIBIT PLATELET-AGGREGATION BY RELEASING A NITRIC OXIDE-LIKE FACTOR
    SALVEMINI, D
    DENUCCI, G
    GRYGLEWSKI, RJ
    VANE, JR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (16) : 6328 - 6332
  • [46] RADIATION CHEMISTRY OF NITRIC OXIDE SOLUTIONS
    SEDDON, WA
    SUTTON, HC
    [J]. TRANSACTIONS OF THE FARADAY SOCIETY, 1963, 59 (490): : 2323 - &
  • [47] INTERCELLULAR ACTION OF NITRIC-OXIDE IN ADULT-RAT CEREBELLAR SLICES
    SOUTHAM, E
    GARTHWAITE, J
    [J]. NEUROREPORT, 1991, 2 (11) : 658 - 660
  • [48] S-NITROSYLATION OF PROTEINS WITH NITRIC-OXIDE - SYNTHESIS AND CHARACTERIZATION OF BIOLOGICALLY-ACTIVE COMPOUNDS
    STAMLER, JS
    SIMON, DI
    OSBORNE, JA
    MULLINS, ME
    JARAKI, O
    MICHEL, T
    SINGEL, DJ
    LOSCALZO, J
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (01) : 444 - 448
  • [49] ACTIVATED MURINE MACROPHAGES SECRETE A METABOLITE OF ARGININE WITH THE BIOACTIVITY OF ENDOTHELIUM-DERIVED RELAXING FACTOR AND THE CHEMICAL-REACTIVITY OF NITRIC-OXIDE
    STUEHR, DJ
    GROSS, SS
    SAKUMA, I
    LEVI, R
    NATHAN, CF
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (03) : 1011 - 1020
  • [50] STUEHR DJ, 1987, CANCER RES, V47, P5590