DIPHENYLPYRAZOLIDINONE AND BENZODIAZEPINE CHOLECYSTOKININ ANTAGONISTS - A CASE OF CONVERGENT EVOLUTION IN MEDICINAL CHEMISTRY

被引：25

作者：

HOWBERT, JJ

LOBB, KL

BRITTON, TC

MASON, NR

BRUNS, RF

机构：

[1] Lilly Research Laboratories, Eli Lilly and Co., Lilly Corporate Center, Indianapolis

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(00)80684-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two recently described classes of nonpeptide cholecystokinin receptor antagonists contain diphenylpyrazolidinone and benzodiazepine substructures, respectively. Although the origins and development of these series were completely independent, the low energy conformations predicted by modeling showed remarkable three-dimensional homology between the structures.

引用

页码：875 / 880

页数：6

共 19 条

[1]

BLOUNT JF, 1983, MOL PHARMACOL, V24, P425

[2] CHOLECYSTOKININ-A RECEPTOR LIGANDS BASED ON THE KAPPA-OPIOID AGONIST TIFLUADOM [J].

BOCK, MG ;

DIPARDO, RM ;

EVANS, BE ;

RITTLE, KE ;

WHITTER, WL ;

VEBER, DF ;

FREIDINGER, RM ;

CHANG, RSL ;

CHEN, TB ;

LOTTI, VJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (01) :450-455

[3] SYNTHESIS AND RESOLUTION OF 3-AMINO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONES [J].

BOCK, MG ;

DIPARDO, RM ;

EVANS, BE ;

RITTLE, KE ;

VEBER, DF ;

FREIDINGER, RM ;

HIRSHFIELD, J ;

SPRINGER, JP .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (15) :3232-3239

[4] BENZODIAZEPINE GASTRIN AND BRAIN CHOLECYSTOKININ RECEPTOR LIGANDS - L-365,260 [J].

BOCK, MG ;

DIPARDO, RM ;

EVANS, BE ;

RITTLE, KE ;

WHITTER, WL ;

VEBER, DF ;

ANDERSON, PS ;

FREIDINGER, RM .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (01) :13-16

[5] METHODS FOR DRUG DISCOVERY - DEVELOPMENT OF POTENT, SELECTIVE, ORALLY EFFECTIVE CHOLECYSTOKININ ANTAGONISTS [J].

EVANS, BE ;

RITTLE, KE ;

BOCK, MG ;

DIPARDO, RM ;

FREIDINGER, RM ;

WHITTER, WL ;

LUNDELL, GF ;

VEBER, DF ;

ANDERSON, PS ;

CHANG, RSL ;

LOTTI, VJ ;

CERINO, DJ ;

CHEN, TB ;

KLING, PJ ;

KUNKEL, KA ;

SPRINGER, JP ;

HIRSHFIELD, J .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (12) :2235-2246

[6] DESIGN OF POTENT, ORALLY EFFECTIVE, NONPEPTIDAL ANTAGONISTS OF THE PEPTIDE-HORMONE CHOLECYSTOKININ [J].

EVANS, BE ;

BOCK, MG ;

RITTLE, KE ;

DIPARDO, RM ;

WHITTER, WL ;

VEBER, DF ;

ANDERSON, PS ;

FREIDINGER, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (13) :4918-4922

[7] DESIGN OF NONPEPTIDAL LIGANDS FOR A PEPTIDE RECEPTOR - CHOLECYSTOKININ ANTAGONISTS [J].

EVANS, BE ;

RITTLE, KE ;

BOCK, MG ;

DIPARDO, RM ;

FREIDINGER, RM ;

WHITTER, WL ;

GOULD, NP ;

LUNDELL, GF ;

HOMNICK, CF ;

VEBER, DF ;

ANDERSON, PS ;

CHANG, RSL ;

LOTTI, VJ ;

CERINO, DJ ;

CHEN, TB ;

KING, PJ ;

KUNKEL, KA ;

SPRINGER, JP ;

HIRSHFIELD, J .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (07) :1229-1239

[8] NOVEL GLUTAMIC-ACID DERIVED CHOLECYSTOKININ RECEPTOR LIGANDS [J].

FREIDINGER, RM ;

WHITTER, WL ;

GOULD, NP ;

HOLLOWAY, MK ;

CHANG, RSL ;

LOTTI, VJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (02) :591-595

[9] CRYSTAL AND MOLECULAR-STRUCTURE OF 7-CHLORO-1,3-DIHYDRO-3-HYDROXY-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE (OXAZEPAM) [J].

GILLI, G ;

BERTOLASI, V ;

SACERDOTI, M ;

BOREA, PA .

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1978, 34 (SEP) :2826-2829

[10]

HOWBERT J J, 1991, Society for Neuroscience Abstracts, V17, P491

← 1 2 →