COPPER-METALLOTHIONEIN INDUCTION IN THE LIVER OF LEC RATS

被引：39

作者：

SAKURAI, H

KAMADA, H

FUKUDOME, A

KITO, M

TAKESHIMA, S

KIMURA, M

OTAKI, N

NAKAJIMA, K

KAWANO, K

HAGINO, T

机构：

[1] KEIO UNIV,SCH MED,TOKYO 160,JAPAN

[2] NATL INST IND HLTH SCI,KANAGAWA 211,JAPAN

[3] JAPAN IMMUNORES LABS CO,GUMMA 370,JAPAN

[4] OTSUKA PHARMACEUT CO LTD,TOKUSHIMA RES INST,TOKUSHIMA 77101,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 185卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91659-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, copper(Cu) was found to be unusually accumulated, suggesting the induction of metallothionein (MT) in the liver of LEC rats (Long-Evans rats with a cinnamon-like coat color), which develop spontaneous jaundice with hereditary hepatitis. Thus, the direct relationship between the unusual Cu accumulation and the induction of Cu-MT was investigated by giving LEC rats Cu-overloaded or Cu-deficient diets. Results based on the determinations of Cu and MT levels in several organs, as well as the gel-filtration profiles of the cytosols of liver homogenates, showed that dietary Cu induced Cu-MT and development of hepatic injury associated with jaundice. © 1992.

引用

页码：548 / 552

页数：5

共 9 条

[1]

HEYDORN K, 1983, METAL ION BIOL SYSTE, V6, P123

[2] PATHOLOGICAL AND LABORATORY FINDINGS IN LEC OTK RATS THAT SPONTANEOUSLY DEVELOP HEPATIC-INJURY [J].

KAWANO, K ;

HIRASHIMA, T ;

MORI, S ;

BANDO, S ;

YONEMOTO, K ;

ABE, F ;

GOTO, H ;

NATORI, T .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1991, 6 (04) :377-382

[3] ABNORMAL COPPER ACCUMULATION IN NON-CANCEROUS AND CANCEROUS LIVER-TISSUES OF LEC RATS DEVELOPING HEREDITARY HEPATITIS AND SPONTANEOUS HEPATOMA [J].

LI, Y ;

TOGASHI, Y ;

SATO, S ;

EMOTO, T ;

KANG, JH ;

TAKEICHI, N ;

KOBAYASHI, H ;

KOJIMA, Y ;

UNE, Y ;

UCHINO, J .

JAPANESE JOURNAL OF CANCER RESEARCH, 1991, 82 (05) :490-492

[4]

MASUDA MC, 1987, J HERED, V78, P361

[5] HEREDITARY HEPATITIS OF LEC RATS IS CONTROLLED BY A SINGLE AUTOSOMAL RECESSIVE GENE [J].

MASUDA, R ;

YOSHIDA, MC ;

SASAKI, M ;

DEMPO, K ;

MORI, M .

LABORATORY ANIMALS, 1988, 22 (02) :166-169

[6]

NAKAJIMA K, 1992, METHOD ENZYMOL, V205, P387

[7] CORRELATION OF LEVELS OF PT AND SE IN RATS TREATED SIMULTANEOUSLY WITH CISPLATIN AND SODIUM SELENITE [J].

SAKURAI, H ;

TSUCHIYA, K ;

HIRAI, S ;

OKADA, Y ;

HARAGUCHI, H .

NATURWISSENSCHAFTEN, 1988, 75 (08) :405-406

[8]

SAKURAI H, UNPUB

[9]

SASAKI M, 1985, RAT NEWS LETT, V14, P4

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