SYNTHESIS OF AMIDES - AN EFFICIENT AND CHEMOSELECTIVE METHOD FOR THE PREPARATION OF BETA-LACTAM DERIVATIVES RELATED TO HLE INHIBITORS

被引：6

作者：

DIFABIO, R ^{[1
]}

SUMMA, V ^{[1
]}

ROSSI, T ^{[1
]}

机构：

[1] GLAXO RES,I-37100 VERONA,ITALY

来源：

TETRAHEDRON | 1993年 / 49卷 / 11期

关键词：

D O I：

10.1016/S0040-4020(01)80373-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical method for the chemoselective synthesis of amides in presence of the beta-lactam ring has been described, by an efficient coupling reaction between a reactive 2-pyridyl thiolester intermediate and a suitable N-silylamine.

引用

页码：2299 / 2306

页数：8

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