THE BISINDOLYLMALEIMIDE GF 109203X, A SELECTIVE INHIBITOR OF PROTEIN-KINASE-C, DOES NOT INHIBIT THE POTENTIATING EFFECT OF PHORBOL ESTER ON ETHANOL-INDUCED PHOSPHOLIPASE C-MEDIATED HYDROLYSIS OF PHOPHATIDYLETHANOLAMINE

被引：29

作者：

KISS, Z

PHILLIPS, H

ANDERSON, WH

机构：

[1] The Hormel Institute, University of Minnesota, Austin, MN 55912

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1995年 / 1265卷 / 01期

关键词：

PHORBOL ESTER; ETHANOL; BISINDOLYLMALEIMIDE; PHOSPHOLIPASE C; PHOSPHATIDYLETHANOLAMINE;

D O I：

10.1016/0167-4889(94)00242-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate (PMA) either inhibits or stimulates phospholipase C-mediated hydrolysis of phosphatidylethanolamine in the absence or presence of ethanol, respectively. Here, we demonstrate that the specific PKC inhibitor bisindolylmaleimide GF 109203X prevents only the inhibitory, but not the stimulatory, PMA effect.

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页码：93 / 95

页数：3

相关论文

共 14 条

[1] HUMAN PRIMARY BRAIN-TUMOR METABOLISM INVIVO - A PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPY STUDY [J].

CADOUXHUDSON, TAD ;

BLACKLEDGE, MJ ;

RAJAGOPALAN, B ;

TAYLOR, DJ ;

RADDA, GK .

BRITISH JOURNAL OF CANCER, 1989, 60 (03) :430-436

[2]

DALY PF, 1987, J BIOL CHEM, V262, P14875

[3] ABNORMAL PHOSPHOMONOESTER SIGNALS IN P-31 MR SPECTRA FROM PATIENTS WITH HEPATIC LYMPHOMA - A POSSIBLE MARKER OF LIVER INFILTRATION AND RESPONSE TO CHEMOTHERAPY [J].

DIXON, RM ;

ANGUS, PW ;

RAJAGOPALAN, B ;

RADDA, GK .

BRITISH JOURNAL OF CANCER, 1991, 63 (06) :953-958

[4] ISOQUINOLINESULFONAMIDES, NOVEL AND POTENT INHIBITORS OF CYCLIC-NUCLEOTIDE DEPENDENT PROTEIN-KINASE AND PROTEIN KINASE-C [J].

HIDAKA, H ;

INAGAKI, M ;

KAWAMOTO, S ;

SASAKI, Y .

BIOCHEMISTRY, 1984, 23 (21) :5036-5041

[5] PHOSPHOMONOESTER IS ASSOCIATED WITH PROLIFERATION IN HUMAN BREAST-CANCER - A P-31 MRS STUDY [J].

KALRA, R ;

WADE, KE ;

HANDS, L ;

STYLES, P ;

CAMPLEJOHN, R ;

GREENALL, M ;

ADAMS, GE ;

HARRIS, AL ;

RADDA, GK .

BRITISH JOURNAL OF CANCER, 1993, 67 (05) :1145-1153

[6]

KALRA R, 1991, SOC MAG RES MED SAN, V2, P628

[7] ETHANOL POTENTIATES THE STIMULATORY EFFECTS OF PHORBOL ESTER, SPHINGOSINE AND 4-HYDROXYNONENAL ON THE HYDROLYSIS OF PHOSPHATIDYLETHANOLAMINE IN NIH 3T3 CELLS [J].

KISS, Z ;

CRILLY, K ;

CHATTOPADHYAY, J .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 197 (03) :785-790

[8] THE LONG-TERM COMBINED STIMULATORY EFFECTS OF ETHANOL AND PHORBOL ESTER ON PHOSPHATIDYLETHANOLAMINE HYDROLYSIS ARE MEDIATED BY A PHOSPHOLIPASE-C AND PREVENTED BY OVEREXPRESSED ALPHA-PROTEIN KINASE-C IN FIBROBLASTS [J].

KISS, Z .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1992, 209 (01) :467-473

[9]

KISS Z, 1989, J BIOL CHEM, V264, P1483

[10] CARCINOGENS STIMULATE PHOSPHORYLATION OF ETHANOLAMINE DERIVED FROM INCREASED HYDROLYSIS OF PHOSPHATIDYLETHANOLAMINE IN C3H/101/2 FIBROBLASTS [J].

KISS, Z ;

CRILLY, KS ;

ANDERSON, WH .

FEBS LETTERS, 1993, 336 (01) :115-118