PERSISTENCE OF THE ABILITY OF AMPHETAMINE PREEXPOSURE TO FACILITATE ACQUISITION OF COCAINE SELF-ADMINISTRATION

被引:78
作者
VALADEZ, A [1 ]
SCHENK, S [1 ]
机构
[1] TEXAS A&M UNIV SYST,DEPT PSYCHOL,COLL STN,TX 77843
关键词
COCAINE; AMPHETAMINE; SELF-ADMINISTRATION; SENSITIZATION;
D O I
10.1016/0091-3057(94)90132-5
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
This study assessed the enduring effects of amphetamine preexposure on the subsequent reinforcing effects of cocaine. Rats received nine daily injections of either d-amphetamine SO4 (2.0 mg/kg, IP) or vehicle 45 days prior to testing of the acquisition of cocaine (0.25 mg/kg/infusion) self-administration, The latency to acquire reliable cocaine self-administration was shorter (day 3) in the amphetamine-preexposed rats than in the vehicle-preexposed rats (day 6). These data are comparable to those observed when testing was carried out 1 day following the treatment. In previous studies, shorter latencies to acquisition also occurred when the training dose of cocaine was increased, suggesting that the treatment had sensitized rats to cocaine's reinforcing properties. These effects of amphetamine exposure persist for 45 days following treatment, which suggest a long-lasting phenomenon.
引用
收藏
页码:203 / 205
页数:3
相关论文
共 19 条
[11]   ENDURING CHANGES IN BRAIN AND BEHAVIOR PRODUCED BY CHRONIC AMPHETAMINE ADMINISTRATION - A REVIEW AND EVALUATION OF ANIMAL-MODELS OF AMPHETAMINE PSYCHOSIS [J].
ROBINSON, TE ;
BECKER, JB .
BRAIN RESEARCH REVIEWS, 1986, 11 (02) :157-198
[12]   DEVELOPMENT AND EXPRESSION OF SENSITIZATION TO COCAINE REINFORCING PROPERTIES - ROLE OF NMDA RECEPTORS [J].
SCHENK, S ;
VALADEZ, A ;
MCNAMARA, C ;
HOUSE, DT ;
HIGLEY, D ;
BANKSON, MG ;
GIBBS, S ;
HORGER, BA .
PSYCHOPHARMACOLOGY, 1993, 111 (03) :332-338
[13]   PREEXPOSURE TO AMPHETAMINE BUT NOT NICOTINE SENSITIZES RATS TO THE MOTOR ACTIVATING EFFECT OF COCAINE [J].
SCHENK, S ;
SNOW, S ;
HORGER, BA .
PSYCHOPHARMACOLOGY, 1991, 103 (01) :62-66
[14]  
SCHENK S, IN PRESS BEHAV PHARM
[15]   PARALLEL PROCESSING STRATEGIES IN THE APPLICATION OF MICROCOMPUTERS TO THE BEHAVIORAL LABORATORY [J].
SPENCER, DG ;
EMMETTOGLESBY, MW .
BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS, 1985, 17 (02) :294-300
[17]   A PSYCHOMOTOR STIMULANT THEORY OF ADDICTION [J].
WISE, RA ;
BOZARTH, MA .
PSYCHOLOGICAL REVIEW, 1987, 94 (04) :469-492
[18]   EFFECTS OF REPEATED METHAMPHETAMINE ADMINISTRATION ON METHAMPHETAMINE SELF-ADMINISTRATION IN RHESUS-MONKEYS [J].
WOOLVERTON, WL ;
CERVO, L ;
JOHANSON, CE .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1984, 21 (05) :737-741
[19]  
ZAHNISER NR, 1992, COCAINE PHARM PHYSL