SIN3 WORKS THROUGH 2 DIFFERENT PROMOTER ELEMENTS TO REGULATE INO1 GENE-EXPRESSION IN YEAST

被引：24

作者：

SLEKAR, KH ^{[1
]}

HENRY, SA ^{[1
]}

机构：

[1] CARNEGIE MELLON UNIV,DEPT BIOL SCI,PITTSBURGH,PA 15213

来源：

NUCLEIC ACIDS RESEARCH | 1995年 / 23卷 / 11期

关键词：

D O I：

10.1093/nar/23.11.1964

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The SIN3 global regulatory factor affects expression of many yeast genes, including the phospholipid biosynthetic gene, INO1. Mutations in the SIN3 gene result in elevated levels of INO1 expression under conditions that normally confer full repression of INO1 transcription, indicating that SIN3 is a negative regulator of INO1. In this study, the INO1 promoter was analyzed for sequences that play a role in responding to SIN3 mediated repression. Two distinct promoter elements, the upstream repression sequence (URS1) and the INO1 upstream activation sequence (UAS(INO)) both were found to be involved in enabling SIN3 to repress INO1 expression.

引用

页码：1964 / 1969

页数：6

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