Low-and High-Tech Approaches to Control Plasmodium Parasite Transmission by Anopheles Mosquitoes

被引：19

作者：

Cirimotich, Chris M. ^{[1
]}

Clayton, April M. ^{[1
]}

Dimopoulos, George ^{[1
]}

机构：

[1] Johns Hopkins Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, 615 N.Wolfe St, Baltimore, MD 21205 USA

来源：

JOURNAL OF TROPICAL MEDICINE | 2011年 / 2011卷

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1155/2011/891342

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 [公共卫生与预防医学]; 120402 [社会医学与卫生事业管理];

摘要：

Current efforts have proven inadequate to stop the transmission of Plasmodium parasites, and hence the spread of malaria, by Anopheles mosquitoes. Therefore, a novel arsenal of strategies for inhibiting Plasmodium infection of mosquitoes is urgently needed. In this paper, we summarize research on two approaches to malaria control, a low-tech strategy based on parasite inhibition by the mosquito's natural microflora, and a high-tech strategy using genetic modification of mosquitoes that renders them resistant to infection and discuss advantages and disadvantages for both approaches.

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