2',3'-DIDEOXYINOSINE (DDI) - ITS CHEMICAL-STABILITY AND CYCLODEXTRIN COMPLEXATION IN AQUEOUS-MEDIA

被引：11

作者：

BEKERS, O

BEIJNEN, JH

TANK, MJTK

BURGER, DM

MEENHORST, PL

LOMBARTS, AJPF

UNDERBERG, WJM

机构：

[1] UNIV UTRECHT,FAC PHARM,DEPT PHARMACEUT ANAL,3508 TD UTRECHT,NETHERLANDS

[2] SLOTERVAART HOSP,NETHERLANDS CANC INST,DEPT PHARM,1066 EC AMSTERDAM,NETHERLANDS

[3] SLOTERVAART HOSP,DEPT INTERNAL MED,1066 EC AMSTERDAM,NETHERLANDS

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1993年 / 11卷 / 06期

关键词：

2'; 3'-DIDEOXYINOSINE; HPLC; CHEMICAL STABILITY; CYCLODEXTRIN COMPLEXATION;

D O I：

10.1016/0731-7085(93)80162-T

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The chemical stability of 2',3'-dideoxyinosine has been studied over a wide pH range (0-12). A stability-indicating HPLC method was used to separate the degradation product from the parent drug. The effects of temperature, ionic strength and buffer components on the degradation kinetics were investigated. Furthermore, the influence of some cyclodextrins (alpha-, beta-, HP-beta-, DM-beta- and gamma-cyclodextrin) on the drug stability have been studied.

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收藏

页码：489 / 493

页数：5

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