SURFACE MODIFICATION OF NANOPARTICLES TO OPPOSE UPTAKE BY THE MONONUCLEAR PHAGOCYTE SYSTEM

An overview of recent advances in the surface modification of colloidal particles to oppose uptake by the mononuclear phagocyte system (MPS) is presented. First, we describe the colloidal particles and hydrophilic coating materials investigated, with particular focus on the literature concerning particles other than liposomes. Then the pharmacokinetics and biodistribution of these MPS-opposing systems are summarized. Finally, the mechanism behind the MPS-avoidance phenomenon is discussed in the light of the concept of steric stabilization, We conclude that the literature reviewed provides enough promise for anticipating therapeutic and diagnostic applications of surface-modified nanoparticles.