LYMPHATIC TARGETING OF POLYMERIC NANOPARTICLES AFTER INTRAPERITONEAL ADMINISTRATION IN RATS

被引：68

作者：

MAINCENT, P

THOUVENOT, P

AMICABILE, C

HOFFMAN, M

KREUTER, J

COUVREUR, P

DEVISSAGUET, JP

机构：

[1] CTR HOSP REG UNIV NANCY BRABOIS, MED NUCL LAB, F-54511 VANDOEUVRE LES NANCY, FRANCE

[2] POLYCLIN ESSEY NANCY, F-54270 ESSEYS LES NANCY, FRANCE

[3] UNIV FRANKFURT, INST PHARMACEUT TECHNOL, W-6000 FRANKFURT 1, GERMANY

[4] CTR ETUD PHARMACEUT, PHARM GALEN & BIOPHARM LAB, CNRS, UA-1218, F-92290 CHATENAY MALABRY, FRANCE

来源：

PHARMACEUTICAL RESEARCH | 1992年 / 9卷 / 12期

关键词：

LYMPHATIC TARGETING; INTRAPERITONEAL ADMINISTRATION; POLYACRYLIC NANOPARTICLES; RATS;

D O I：

10.1023/A:1015895804597

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Following intraperitoneal administration, the lymphatic targeting of polyacrylic nanoparticles has been evaluated in thoracic duct cannulated rats. The dosage forms administered consisted of carbon-14 polyhexylcyanoacrylate nanoparticles (PHCA) and polymethylmethacrylate (PMMA) nanoparticles. The carbon-14 concentrations were much higher in the excreted thoracic lymph than in the blood for both types of particles. The most dramatic results were found in the mediastinal nodes since the carbon-14 concentrations of rats receiving PHCA and PMMA nanoparticles by the ip route were 70- to more than 2000-fold higher than in the corresponding nodes of animals treated by the intravenous route. This potential lymphatic targeting could prove valuable in cancerology to treat tumors that metastasize in the peritoneal cavity or via lymphatic pathways such as colon carcinomas.

引用

页码：1534 / 1539

页数：6

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