ADDITIVE EFFECT OF LITHIUM AND CLONIDINE WITH 5HT(1A) AGONISTS IN THE FORCED SWIMMING TEST

被引：24

作者：

HASCOET, M ^{[1
]}

BOURIN, M ^{[1
]}

KHIMAKE, S ^{[1
]}

机构：

[1] FAC MED NANTES, DEPT PHARMACOL & GIS MEDICAMENT, PHARMACOL LAB, F-44035 NANTES, FRANCE

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1994年 / 18卷 / 02期

关键词：

ANTIDEPRESSANT; CLONIDINE; FORCED SWIMMING TEST; 5HT1A AGONISTS; LITHIUM;

D O I：

10.1016/0278-5846(94)90070-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. The aim of the present work was to demonstrate the possible additive effect of lithium and clonidine with 5HT1a agonists in the forced swimming test. 2. Anti-depressant like effects of 5HT1a agonists was investigated using forced swimming test. When administred alone, only 8OHDPAT reduced the immobility time in mice. 3. 5HT1a agonists were then tested in combination with clonidine or lithium. Only gepirone and ipsapirone pretreated by either lithium or clonidine reduced immobility time in the forced swimming test. 4. The authors conclude that lithium and clonidine might be useful to predict antidepressant-like activity of new coumpounds.

引用

页码：381 / 396

页数：16

共 28 条

[1]

AMSTERDAM JD, 1987, CURR THER RES CLIN E, V41, P185

[2] SHORT-TERM LITHIUM ADMINISTRATION ENHANCES SEROTONERGIC NEUROTRANSMISSION - ELECTROPHYSIOLOGICAL EVIDENCE IN THE RAT CNS [J].

BLIER, P ;

DEMONTIGNY, C .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 113 (01) :69-77

[3]

BOURIN M, 1991, J PSYCHIATR NEUROSCI, V16, P199

[4] POTENTIAL ANTIDEPRESSANT PROPERTIES OF 8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN, A SELECTIVE SEROTONIN-1A RECEPTOR AGONIST [J].

CERVO, L ;

SAMANIN, R .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 144 (02) :223-229

[5] DIFFERENT EFFECTS OF INTRACEREBRAL AND SYSTEMIC ADMINISTRATION OF BUSPIRONE IN THE FORCED SWIMMING TEST - INVOLVEMENT OF A METABOLITE [J].

CERVO, L ;

GRIGNASCHI, G ;

SAMANIN, R .

LIFE SCIENCES, 1988, 43 (25) :2095-2102

[6] LITHIUM INDUCES RAPID RELIEF OF DEPRESSION IN TRICYCLIC ANTI-DEPRESSANT DRUG NON-RESPONDERS [J].

DEMONTIGNY, C ;

GRUNBERG, F ;

MAYER, A ;

DESCHENES, JP .

BRITISH JOURNAL OF PSYCHIATRY, 1981, 138 (MAR) :252-256

[7]

DEMONTIGNY C, 1991, BIOL PSYCHIAT, V1, P301

[8]

EROGLU L, 1987, POL J PHARMACOL PHAR, V39, P667

[9] IDENTIFICATION OF PRE-SYNAPTIC SEROTONIN AUTORECEPTORS USING A NEW LIGAND - H-3-PAT [J].

GOZLAN, H ;

ELMESTIKAWY, S ;

PICHAT, L ;

GLOWINSKI, J ;

HAMON, M .

NATURE, 1983, 305 (5930) :140-142

[10]

HASCOET M, 1993, IN PRESS POSTER NEUR

← 1 2 3 →