THE NOVEL HYDROXYNAPHTHOQUINONE 566C80 INHIBITS THE DEVELOPMENT OF LIVER STAGES OF PLASMODIUM-BERGHEI CULTURED INVITRO

被引：31

作者：

DAVIES, CS

PUDNEY, M

NICHOLAS, JC

SINDEN, RE

机构：

[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED, DEPT PURE & APPL BIOL, LONDON SW7 2BB, ENGLAND

[2] WELLCOME RES LABS, DEPT MOLEC SCI, BECKENHAM BR3 3BS, KENT, ENGLAND

来源：

PARASITOLOGY | 1993年 / 106卷

关键词：

PLASMODIUM-BERGHEI; EXO-ERYTHROCYTIC STAGES; HYDROXYNAPHTHOQUINONE; PYRIMETHAMINE;

D O I：

10.1017/S0031182000074746

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The causal prophylactic activity of the novel hydroxynaphthoquinone, 566C80, was assessed against the exo-erythrocytic (EE) stages of Plasmodium berghei cultured in the human hepatoma cell line, HepG2. 566C80 was found to be highly active as an inhibitor of EE development and was more active than the established causal prophylactic pyrimethamine. A 566C80 concentration of 1.85 x 10(-9) M, added 3 h after sporozoite invasion, reduced the numbers of EE forms visible at 48 h by 50 %, while the equivalent concentration of pyrimethamine was 1.95 x 10(-8) m.

引用

页码：1 / 6

页数：6

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