PERICENTRIC REGION OF CHROMOSOME-9 IS A POSSIBLE CANDIDATE REGION FOR LINKAGE STUDY OF SCHIZOPHRENIA

被引：31

作者：

NANKO, S

KUNUGI, H

SASAKI, T

FUKUDA, R

KAWATE, T

KAZAMATSURI, H

机构：

[1] Department of Psychiatry, Teikyo University School of Medicine, Kaga, Itabashi, Tokyo

来源：

BIOLOGICAL PSYCHIATRY | 1993年 / 33卷 / 8-9期

关键词：

SCHIZOPHRENIA; LINKAGE STUDY; CHROMOSOME-9; PERICENTRIC INVERSION;

D O I：

10.1016/0006-3223(93)90107-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have undertaken a systematic G-banding survey to find structural chromosomal abnormalities among patients with schizophrenia. Of 120 patients with DSM-III-R schizophrenia, four (3.3%) had a pericentric inversion of chromosome 9 and three (2.5%) had a X/XX mosaicism. The frequency of pericentric inversion of chromosome 9 among patients with schizophrenia was statistically higher than those among newborns and Asian populations. Our results indicate that the pericentric region of chromosome 9 might be one of the potential regions of interest for linkage analysis of schizophrenia.

引用

页码：655 / 658

页数：4

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