HUMAN-LEUKOCYTE ANTIGENS AND NATURAL-SELECTION BY MALARIA

被引：54

作者：

HILL, AVS ^{[1
]}

YATES, SNR ^{[1
]}

ALLSOPP, CEM ^{[1
]}

GUPTA, S ^{[1
]}

GILBERT, SC ^{[1
]}

LALVANI, A ^{[1
]}

AIDOO, M ^{[1
]}

DAVENPORT, M ^{[1
]}

PLEBANSKI, M ^{[1
]}

机构：

[1] UNIV OXFORD, DEPT ZOOL, OXFORD OX1 3PS, ENGLAND

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 1994年 / 346卷 / 1317期

关键词：

D O I：

10.1098/rstb.1994.0155

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The extraordinary polymorphism of human leukocyte antigens (KLA) poses a question as to how this remarkable diversity arose and is maintained. The explanation that infectious pathogens are largely responsible is theoretically attractive but clear and consistent associations between HLA alleles and major infectious diseases have rarely been identified. Large case-control studies of HLA types in African children with severe malaria indicate that HLA associations with this parasitic infection do exist and it is becoming possible to investigate the underlying mechanisms by identification of peptide epitopes in parasite antigens. Such analysis reveals how the magnitude and detectability of HLA associations may be influenced by numerous genetic and environmental factors. These complex interactions will give rise to variation over time and space in the selective pressures exerted by infectious diseases and this fluctuation may, in itself, contribute to the maintenance of HLA polymorphism.

引用

页码：379 / 385

页数：7

共 38 条

[1] A MALARIA CONTROL TRIAL USING INSECTICIDE-TREATED BED NETS AND TARGETED CHEMOPROPHYLAXIS IN A RURAL AREA OF THE GAMBIA, WEST-AFRICA .6. THE IMPACT OF THE INTERVENTIONS ON MORTALITY AND MORBIDITY FROM MALARIA [J].