CLINICAL ISSUES IN ANTIBODY DESIGN

被引：64

作者：

CHESTER, KA ^{[1
]}

HAWKINS, RE ^{[1
]}

机构：

[1] MRC CTR,DEPT ONCOL,CAMBRIDGE CB2 2HQ,ENGLAND

来源：

TRENDS IN BIOTECHNOLOGY | 1995年 / 13卷 / 08期

关键词：

D O I：

10.1016/S0167-7799(00)88968-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Antibody genes can now be cloned and expressed in various ways to give new versions of antibodies that possess reduced immunogenicity, improved affinity, altered size, increased avidity and novel effector functions. The task for any clinical application is, first, to define a relevant target, and then to design the optimal antibody-based therapeutic molecule to react with that target. This article reviews these improved antibody-based molecules and examines their role in cancer therapy.

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页码：294 / 300

页数：7

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