SERUM SURFACTANT PROTEIN-A LEVELS IN PATIENTS WITH ACUTE CARDIOGENIC PULMONARY-EDEMA AND ADULT-RESPIRATORY-DISTRESS-SYNDROME

被引：95

作者：

DOYLE, IR

NICHOLAS, TE

BERSTEN, AD

机构：

[1] FLINDERS MED CTR, SCH MED, INTENS CARE UNIT, BEDFORD PK, SA 5042, AUSTRALIA

[2] FLINDERS MED CTR, SCH MED, DEPT HUMAN PHYSIOL, BEDFORD PK, SA 5042, AUSTRALIA

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 1995年 / 152卷 / 01期

关键词：

D O I：

10.1164/ajrccm.152.1.7599839

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Detection of alveole-capillary damage has important implications for treatment modalities in ventilated patients. Although surfactant protein-A (SP-A) is normally only found in appreciable amounts in the lung, we describe significantly elevated concentrations in the sera of patients with acute cardiogenic pulmonary edema (median, 250 ng/ml; range, 180 to 364; n = 10) and in those with the adult respiratory distress syndrome (ARDS) (median, 378 ng/ml; range, 215 to 1,378; n = 15) relative to healthy control subjects (median, 175 ng/ml; range, 123 to 248; n = 15) and ventilated patients with no cardiorespiratory disease (median, 169 ng/ml; range, 126 to 253; n = 6) (p < 0.01, in all cases). Serum SP-A was inversely related to blood oxygenation and to static respiratory system compliance both at the time of the patient's entry into the study (p < 0.005, r(s) = -0.51, n = 31; p < 0.001, r(s) = 0.82, n = 17; respectively) and during the course of admission (p < 0.001, r(s) = -0.34, n = 168; p < 0.001, r(s) = -0.50, n = 111; respectively). In addition, we describe in detail three cases of ARDS where lung function either improved, remained static, or deteriorated. We conclude that serum SP-A is an acute indicator of lung function and alveolo-capillary membrane injury.

引用

页码：307 / 317

页数：11

共 46 条

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