MORPHOLOGIC EFFECTS OF CIGARETTE-SMOKING ON AIRWAYS AND PULMONARY PARENCHYMA IN HEALTHY ADULT VOLUNTEERS - CT EVALUATION AND CORRELATION WITH PULMONARY-FUNCTION TESTS

被引：148

作者：

REMYJARDIN, M ^{[1
]}

REMY, J ^{[1
]}

BOULENGUEZ, C ^{[1
]}

SOBASZEK, A ^{[1
]}

EDME, JL ^{[1
]}

FURON, D ^{[1
]}

机构：

[1] UNIV LILLE, ENVIRONM & OCCUPAT HLTH & ERGONOM RES CTR, LILLE, FRANCE

来源：

RADIOLOGY | 1993年 / 186卷 / 01期

关键词：

BRONCHI; ABNORMALITIES; BRONCHIOLITIS; COMPUTED TOMOGRAPHY (CT); HIGH RESOLUTION; EMPHYSEMA; LUNG; CT; DISEASES; FUNCTION; NODULE;

D O I：

10.1148/radiology.186.1.8416548

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A prospective computed tomographic (CT) study was performed to determine the prevalence of lung changes in smokers. The study group comprised 175 healthy adult volunteers (current smokers, n = 98; ex-smokers, n = 26; nonsmokers, n = 51). The subjects underwent clinical examination, pulmonary function tests, chest radiography, and conventional and high-resolution CT (HRCT). Significant differences between current smokers, ex-smokers, and nonsmokers were observed with HRCT in the identification of subpleural (P = .11) and parenchymal (P < .001) micronodules, emphysema (P < .001), and areas of ground-glass attenuation (P = .0001). All subjects had normal pulmonary function. Parenchymal micronodules, areas of ground-glass attenuation, and emphysema were observed with a significant predominance in the upper lung zones (P < .01). Presence of emphysema and abnormal bronchial wall thickening were the only HRCT signs associated with significantly lower values of functional parameters. These data support the concept that parenchymal abnormalities can be detected in healthy smokers with normal findings at chest radiography and pulmonary function tests.

引用

页码：107 / 115

页数：9

共 37 条

[11]

COSIO MG, 1980, AM REV RESPIR DIS, V122, P265

[12] EARLY EMPHYSEMA - 10 YEARS EVOLUTION [J].

DEMEDTS, M ;

AUMANN, J .

CHEST, 1988, 94 (02) :337-342

[13] EFFECT OF CIGARETTE-SMOKING ON EVOLUTION OF VENTILATORY LUNG-FUNCTION IN YOUNG-ADULTS - AN 8 YEAR LONGITUDINAL-STUDY [J].

JAAKKOLA, MS ;

ERNST, P ;

JAAKKOLA, JJK ;

NGANGA, LW ;

BECKLAKE, MR .

THORAX, 1991, 46 (12) :907-913

[14] HIGH-RESOLUTION CT DIAGNOSIS OF EMPHYSEMA IN SYMPTOMATIC PATIENTS WITH NORMAL CHEST RADIOGRAPHS AND ISOLATED LOW DIFFUSING-CAPACITY [J].

KLEIN, JS ;

GAMSU, G ;

WEBB, WR ;

GOLDEN, JA ;

MULLER, NL .

RADIOLOGY, 1992, 182 (03) :817-821

[15]

KNUDSON RJ, 1983, AM REV RESPIR DIS, V127, P725

[16] SUBCLINICAL EFFECTS OF CIGARETTE-SMOKING - A 5-YEAR FOLLOW-UP OF PHYSIOLOGIC COMPARISONS OF HEALTHY MIDDLE-AGED SMOKERS AND NONSMOKERS [J].

KNUDSON, RJ ;

KNUDSON, DE ;

KALTENBORN, WT ;

BLOOM, JW .

CHEST, 1989, 95 (03) :512-518

[17]

KOEHLER PR, 1979, RADIOLOGY, V130, P189

[18] THE DIAGNOSIS OF MILD EMPHYSEMA - CORRELATION OF COMPUTED-TOMOGRAPHY AND PATHOLOGY SCORES [J].

KUWANO, K ;

MATSUBA, K ;

IKEDA, T ;

MURAKAMI, J ;

ARAKI, A ;

NISHITANI, H ;

ISHIDA, T ;

YASUMOTO, K ;

SHIGEMATSU, N .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 141 (01) :169-178

[19]

MENEELY GR, 1962, AM REV RESPIR DIS, V85, P762

[20]

MILNE E N C, 1969, Journal of the Canadian Association of Radiologists, V20, P3

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