SYNTHESIS OF A BETA-MANNOSYL-CHITOBIOSYL-ASPARAGINE CONJUGATE - A CENTRAL CORE REGION UNIT OF THE N-GLYCOPROTEINS

被引：60

作者：

GUNTHER, W ^{[1
]}

KUNZ, H ^{[1
]}

机构：

[1] UNIV MAINZ,INST ORGAN CHEM,JOH JOACHIM BECHER WEG 18-20,W-6500 MAINZ,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1990年 / 29卷 / 09期

关键词：

D O I：

10.1002/anie.199010501

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The correct β‐glycosidic linkage between mannose and chitobiosyl‐asparagine residues in N‐glycoproteins was achieved synthetically for the first time in the construction of 1. Decisive is the intramolecular nucleophilic substitution in 2; the product of this reaction was transformed, via a trisaccharide and a trisaccharide isothiocyanate, into the asparagine derivative 1. (Figure Presented.) Copyright © 1990 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：1050 / 1051

页数：2

共 14 条

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