MARKED DECREASE OF A10-DOPAMINE NEURONAL FIRING DURING ETHANOL WITHDRAWAL SYNDROME IN RATS

被引：42

作者：

DIANA, M

PISTIS, M

MUNTONI, A

ROSSETTI, ZL

GESSA, G

机构：

[1] 'B.B. Brodie' Department of Neuroscience, University of Cagliari, 09124 Cagliari

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 221卷 / 2-3期

关键词：

DOPAMINE NEURONS; ETHANOL; WITHDRAWAL SYNDROME;

D O I：

10.1016/0014-2999(92)90734-L

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The electrophysiological activity of mesoaccumbens dopaminergic neurons was monitored during the ethanol-withdrawal syndrome in ethanol-dependent and in control rats. Spontaneous firing was reduced by about half in ethanol-dependent rats as compared to controls. Likewise, the number of spikes/burst was also reduced in ethanol-dependent rats. These results are consistent with the reduction in dopamine release observed during ethanol-withdrawal syndrome and may provide the basis for the aversive effects of the ethanol-withdrawal syndrome.

引用

页码：403 / 404

页数：2

共 5 条

[1] DICHIARA G, 1988, P NATL ACAD SCI USA, V85, P5274
[2] LOW-DOSES OF ETHANOL ACTIVATE DOPAMINERGIC-NEURONS IN THE VENTRAL TEGMENTAL AREA
GESSA, GL
MUNTONI, F
COLLU, M
VARGIU, L
MEREU, G
[J]. BRAIN RESEARCH, 1985, 348 (01) : 201 - 203
[3] IMPERATO A, 1986, J PHARMACOL EXP THER, V239, P219
[4] TEMPORAL RELATIONSHIP OF INDUCTION OF TOLERANCE AND PHYSICAL-DEPENDENCE AFTER CONTINUOUS INTOXICATION WITH MAXIMUM TOLERABLE DOSES OF ETHANOL IN RATS
MAJCHROWICZ, E
HUNT, WA
[J]. PSYCHOPHARMACOLOGY, 1976, 50 (02) : 107 - 112
[5] ALCOHOL-WITHDRAWAL IN RATS IS ASSOCIATED WITH A MARKED FALL IN EXTRANEURONAL DOPAMINE
ROSSETTI, ZL
MELIS, F
CARBONI, S
DIANA, M
GESSA, GL
[J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1992, 16 (03) : 529 - 532

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