IMMUNOGENICITY OF COMBINED ANTI-HIV AND ANTISUPPRESSIVE VACCINE PREPARATIONS

被引：12

作者：

CARELLI, C

HALBREICH, A

BERNARD, J

BIZZINI, B

ACHOUR, A

ZAGURY, JF

LEBON, P

POLLIOTTI, B

FOLGHERA, S

LAAROUBI, K

ABOUDPIRAK, E

LOWELL, G

BURNY, A

PICARD, O

ZAGURY, D

机构：

[1] UNIV PARIS 06,PHYSIOL CELLULAIRE LAB,F-75230 PARIS 05,FRANCE

[2] INST JEAN GODINOI,IMMUNOL LAB,F-51056 REIMS,FRANCE

[3] INST PASTEUR,F-75724 PARIS 15,FRANCE

[4] HOP ST VINCENT DE PAUL,F-75674 PARIS 14,FRANCE

[5] WEIZMANN INST SCI,IL-76100 REHOVOT,ISRAEL

[6] WALTER REED ARMY MED CTR,USA,RES UNIT ISRAEL,WASHINGTON,DC 20307

[7] UNIV LIBRE BRUXELLES,B-1050 BRUSSELS,BELGIUM

[8] HOP ST ANTOINE,F-75571 PARIS 12,FRANCE

来源：

BIOMEDICINE & PHARMACOTHERAPY | 1992年 / 46卷 / 04期

关键词：

HIV-1; VACCINE; IMMUNOSUPPRESSION; PEPTIDES;

D O I：

10.1016/0753-3322(92)90022-Y

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

HIV-1 antigens generate in man both a humoral and cellular immune reaction. However, in ARC/AIDS patients, the cellular response is inhibited by HIV-1 which induces an antiproliferative (suppressive) effect on activated T cells. To overcome this inhibition and up-regulate the cellular response, we designed a new vaccine strategy directed both against HIV-1 and immunosuppression and we used an immunizing preparation composed of HIV-1 antigens combined with immunoregulatory peptides prepared in a biologically inactivated but immunogenic form. In mice, this preparation induced anti-HIV-1 antibodies and a cell-mediated cytotoxicity directed against H2 restricted cells carrying HIV-1 antigens.

引用

页码：149 / 153

页数：5