DETECTION OF NEW 7-0-ACYL DERIVATIVES OF DIARRHETIC SHELLFISH POISONING TOXINS BY LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY

被引:102
作者
MARR, JC [1 ]
HU, T [1 ]
PLEASANCE, S [1 ]
QUILLIAM, MA [1 ]
WRIGHT, JLC [1 ]
机构
[1] NATL RES COUNCIL CANADA,ATLANTIC REG LAB,INST MARINE BIOSCI,HALIFAX B3H 3Z1,NS,CANADA
关键词
D O I
10.1016/0041-0101(92)90034-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A novel method for the detection of acylated diarrhetic shellfish poisoning toxins is reported. Direct determination of these compounds is possible using high performance liquid chromatography coupled with ion-spray mass spectrometry. An extract, purified from the digestive glands of toxic mussels (Mytilus edulis) contaminated with okadaic acid, dinophysistoxin-1, and a recently reported analog, dinophysistoxin-2, was also shown to contain small amounts of dinophysistoxin-3, a mixture of 7-O-acyl ester derivatives of dinophysistoxin-1. In addition, acyl ester derivatives of okadaic acid and dinophysistoxin-2 were also detected by direct LC-MS analysis and confirmed by analysis of their hydrolysis products. This is the first report of the detection of other naturally occurring 7-O-acyl esters similar to dinophysistoxin-3.
引用
收藏
页码:1621 / 1630
页数:10
相关论文
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