COMPARATIVE MAPPING OF MOUSE CHROMOSOME-4 AND HUMAN CHROMOSOME-9 - LV, ORM, AND HXB ARE CLOSELY LINKED ON MOUSE CHROMOSOME-4

被引：12

作者：

PILZ, A

MOSELEY, H

PETERS, J

ABBOTT, C

机构：

[1] UNIV LONDON UNIV COLL,DEPT GENET & BIOMETRY,LONDON NW1 2HE,ENGLAND

[2] MRC,RADIOBIOL UNIT,DIDCOT OX11 ORD,OXON,ENGLAND

来源：

MAMMALIAN GENOME | 1992年 / 3卷 / 05期

关键词：

D O I：

10.1007/BF00292151

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The genes for orosomucoid (ORM-1 and ORM-2), delta-aminolevulinate dehydratase (ALAD), and hexabrachion or tenascin (HXB) all map to the q31-qter region of human Chromosome (Chr) 9. The mouse homolog of each of these genes has been mapped to Chr 4, but hexabrachion has not previously been mapped by linkage analysis. We have now ordered Orm-1, Lv (the mouse homolog of ALAD), and Hxb in an interspecific backcross panel, by use of tyrosinase related protein-1, Tyrp-1, whose human homolog maps to 9p13-pter (Abbott et al., Genomics 1991) as a reference locus. No recombinants were identified in 124 animals between Lv and Orm-1. Hxb was found to be 1.6 cM distal to Lv and Orm-1, and 4.8 cM proximal to Tyrp-1, or b. These data therefore contribute to our knowledge of the conserved synteny between HSA 9q and MMU 4.

引用

页码：247 / 249

页数：3

共 15 条

[1] THE HUMAN HOMOLOG OF THE MOUSE BROWN GENE MAPS TO THE SHORT ARM OF CHROMOSOME-9 AND EXTENDS THE KNOWN REGION OF HOMOLOGY WITH MOUSE CHROMOSOME-4 [J].