A RANDOMIZED, CLINICAL-STUDY OF THE EFFECT OF LOW-DOSE DOPAMINE ON CENTRAL AND RENAL HEMODYNAMICS IN INFRARENAL AORTIC-SURGERY

Objective: To determine whether dopamine prevents deterioration of central hae Design: Prospective, randomised and placebo-controlled. Setting: University hospital. Materials: Thirty patients for elective vascular surgery with implantation of an aortobifemoral or an aortobiiliac graft due to aortoiliac arteriosclerosis had infusion of dopamine 3 mu g/kg/min or placebo during the operation and 24 h postoperatively. Thoracic epidural analgesia and general anaesthesia were used. Chief outcome measures: Central haemodynamic measurements were registered. The effective renal plasma flow (ERPF), the glomerular filtration rate (GFR), angiotensin II, aldosterone, arginine vasopressin (AVP), atrial natriuretic peptide (ANP), endothelin and excretion of Water and electrolytes were measured preoperatively 1 h postoperatively and 24 h postoperatively. Main results: During the operation the dopamine group had higher cardiac index and heart rate together with lower pulmonary artery wedge blood pressure. ERPF and GFX did not differ between the groups. In the dopamine group ERPF was increased in all patients at the fir sl postoperative clearance. The fractional excretion of sodium, the per- and postoperative diuresis and AVP were increased in the dopamine group as compared to the placebo group. Postoperatively, ANP in the placebo group was I raised as compared to the preoperative level. Conclusions: Peroperatively, dopamine counteracted depression of left ventricular function. The increased ERPF at the first postoperative clearance in the dopamine group indicates either improved peroperative haemodynamics or a synergistic effect between dopamine and epidural sympathetic blockade. Dopamine also improved diuresis and natriuresis.