PROOXIDANT ACTIVITY OF BETA-CAROTENE UNDER 100-PERCENT OXYGEN-PRESSURE IN RAT-LIVER MICROSOMES

被引:78
作者
PALOZZA, P
CALVIELLO, G
BARTOLI, GM
机构
[1] UNIV CATTOLICA SACRO CUORE, INST GEN PATHOL, I-00168 ROME, ITALY
[2] UNIV ROMA TOR VERGATA, DEPT BIOL, I-00173 ROME, ITALY
关键词
FREE RADICALS; OXYGEN; BETA-CAROTENE; LIPID PEROXIDATION; RAT LIVER;
D O I
10.1016/0891-5849(95)00094-E
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effects of the partial pressure of oxygen (pO(2)) on antioxidant efficiency of beta-carotene in inhibiting 2,2'-azobis(2-amidinopropane) (AAPH)-induced lipid peroxidation are investigated in rat liver microsomal membranes. The rate of peroxyl radicals generated by thermolysis of AAPH at 37 degrees C is markedly higher at 150 than 760 mm Hg pO,. At 150 mm Hg pO(2) beta-carotene acts as an antioxidant, inhibiting 2,2'-azobis(2-amidinopropane) (AAPH)-induced Malondialdehyde (MDA) formation. At 760 mm Hg pO(2), it loses its antioxidant activity and shows a prooxidant effect, increasing lipid peroxidation products. alpha-Tocopherol prevents the prooxidant effect of beta-carotene in a dose-dependent manner. Our data provide the first evidence of a prooxidant effect of beta-carotene under 100% oxygen pressure in a biological membrane model and point out the existence of cooperative interactions between beta-carotene and alpha-tocopherol.
引用
收藏
页码:887 / 892
页数:6
相关论文
共 33 条
[11]   CHARACTERIZATION OF PRODUCTS FORMED DURING THE AUTOXIDATION OF BETA-CAROTENE [J].
HANDELMAN, GJ ;
VANKUIJK, FJGM ;
CHATTERJEE, A ;
KRINSKY, NI .
FREE RADICAL BIOLOGY AND MEDICINE, 1991, 10 (06) :427-437
[12]   PEROXYL RADICAL OXIDATION OF BETA-CAROTENE - FORMATION OF BETA-CAROTENE EPOXIDES [J].
KENNEDY, TA ;
LIEBLER, DC .
CHEMICAL RESEARCH IN TOXICOLOGY, 1991, 4 (03) :290-295
[13]  
KENNEDY TA, 1992, J BIOL CHEM, V267, P4658
[14]  
KRINSKY NI, 1982, J NATL CANCER I, V69, P205
[15]  
KRINSKY NI, 1993, ANNU REV NUTR, V13, P561, DOI 10.1146/annurev.nutr.13.1.561
[16]   ANTIOXIDANT FUNCTIONS OF CAROTENOIDS [J].
KRINSKY, NI .
FREE RADICAL BIOLOGY AND MEDICINE, 1989, 7 (06) :617-635
[17]  
LIM BP, 1992, BIOCHIM BIOPHYS ACTA, V1126, P178
[18]   ANTIOXIDANTS IN RELATION TO LIPID-PEROXIDATION [J].
NIKI, E .
CHEMISTRY AND PHYSICS OF LIPIDS, 1987, 44 (2-4) :227-253
[19]   EFFECTS OF BETA-CAROTENE AND ALPHA-TOCOPHEROL ON RADICAL-INITIATED PEROXIDATION OF MICROSOMES [J].
PALOZZA, P ;
MOUALLA, S ;
KRINSKY, NI .
FREE RADICAL BIOLOGY AND MEDICINE, 1992, 13 (02) :127-136
[20]   THE INHIBITION OF RADICAL-INITIATED PEROXIDATION OF MICROSOMAL LIPIDS BY BOTH ALPHA-TOCOPHEROL AND BETA-CAROTENE [J].
PALOZZA, P ;
KRINSKY, NI .
FREE RADICAL BIOLOGY AND MEDICINE, 1991, 11 (04) :407-414