ROLE OF NEUTROPHILS IN ENDOTOXIN-MEDIATED MICROVASCULAR INJURY IN HAMSTERS

被引:22
作者
MATSUDA, T
RUBINSTEIN, I
ROBBINS, RA
KOYAMA, S
JOYNER, WL
RENNARD, SI
机构
[1] UNIV NEBRASKA, MED CTR,DEPT INTERNAL MED, PULM & CRIT CARE MED SECT,600 S 42ND ST, OMAHA, NE 68198 USA
[2] UNIV NEBRASKA, MED CTR, DEPT PHYSIOL & BIOPHYS, OMAHA, NE 68198 USA
关键词
MICROVASCULAR CLEARANCE; SEPSIS; BLOOD VESSELS; MECHLORETHAMINE HYDROCHLORIDE; ESCHERICHIA-COLI;
D O I
10.1152/jappl.1991.71.1.307
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The purpose of this study was to examine the role of circulating neutrophils in endotoxin-induced increase in microvascular permeability in vivo. Fifteen hamsters were anesthetized, and a plastic chamber was placed in each cheek pouch to observe the microvasculature. Fluorescein-labeled dextran (FITC-D, 150 kDa) was injected intravenously, and changes in leaky sites and FITC-D clearance were measured in three groups: control (saline, n = 4), endotoxin suffusion (n = 6), and endotoxin suffusion after neutropenia induction (n = 5). We found a significant increase in leaky sites and FITC-D clearance with endotoxin (45 +/- 18/cm2 and 20 +/- 6 x 10(-6) ml/min, respectively; mean +/- SD, P < 0.05) in comparison to control (7 +/- 6/cm2 and 7 +/- 5 x 10(-6) ml/min) and endotoxin suffusion in neutropenic animals (19 +/- 11/cm2 and 12 +/- 4 x 10(-6) ml/min). There was a significant correlation between the number of leaky sites and FITC-D clearance (r = 0.91, P < 0.01) and between the number of circulating neutrophils and FITC-D clearance (r = 0.87, P < 0.01). We conclude that endotoxin-mediated increase in microvascular permeability in the peripheral circulation is dependent in part on circulating neutrophils.
引用
收藏
页码:307 / 313
页数:7
相关论文
共 30 条
  • [21] NEUTROPHIL-MEDIATED VASCULAR LEAKAGE IS NOT SUPPRESSED BY LEUKOCYTE ELASTASE INHIBITORS
    ROSENGREN, S
    ARFORS, KE
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (04): : H1288 - H1294
  • [22] MAST-CELL CHYMASE POTENTIATES HISTAMINE-INDUCED WHEAL FORMATION IN THE SKIN OF RAGWEED-ALLERGIC DOGS
    RUBINSTEIN, I
    NADEL, JA
    GRAF, PD
    CAUGHEY, GH
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (02) : 555 - 559
  • [23] SHASBY DM, 1982, AM REV RESPIR DIS, V125, P443
  • [24] CHEMOTACTIC FACTOR-INDUCED GENERATION OF SUPEROXIDE RADICALS BY HUMAN-NEUTROPHILS - EFFECT OF METABOLIC-INHIBITORS AND ANTI-INFLAMMATORY DRUGS
    SIMCHOWITZ, L
    MEHTA, J
    SPILBERG, I
    [J]. ARTHRITIS AND RHEUMATISM, 1979, 22 (07): : 755 - 763
  • [25] NEUTROPHIL-MEDIATED INJURY TO ENDOTHELIAL-CELLS - ENHANCEMENT BY ENDOTOXIN AND ESSENTIAL ROLE OF NEUTROPHIL ELASTASE
    SMEDLY, LA
    TONNESEN, MG
    SANDHAUS, RA
    HASLETT, C
    GUTHRIE, LA
    JOHNSTON, RB
    HENSON, PM
    WORTHEN, GS
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1986, 77 (04) : 1233 - 1243
  • [26] SVENSJO E, 1986, FASEB J, V45, P89
  • [27] VANDEVENTER SJH, 1988, LANCET, V1, P605
  • [28] INHIBITION OF LEUKOCYTE ADHERENCE BY ANTI-CD18 MONOCLONAL-ANTIBODY ATTENUATES REPERFUSION INJURY IN THE RABBIT EAR
    VEDDER, NB
    WINN, RK
    RICE, CL
    CHI, EY
    ARFORS, KE
    HARLAN, JM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (07) : 2643 - 2646
  • [29] CONTROL OF VASCULAR-PERMEABILITY BY POLYMORPHONUCLEAR LEUKOCYTES IN INFLAMMATION
    WEDMORE, CV
    WILLIAMS, TJ
    [J]. NATURE, 1981, 289 (5799) : 646 - 650
  • [30] NEUTROPHIL DEPLETION DOES NOT PREVENT LUNG EDEMA AFTER ENDOTOXIN INFUSION IN GOATS
    WINN, R
    MAUNDER, R
    CHI, E
    HARLAN, J
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 1987, 62 (01) : 116 - 121