NEUROPROTECTIVE EFFECTS OF GANGLIOSIDES MAY INVOLVE INHIBITION OF NITRIC-OXIDE SYNTHASE

被引：67

作者：

DAWSON, TM

HUNG, K

DAWSON, VL

STEINER, JP

SNYDER, SH

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROSCI, BALTIMORE, MD 21205 USA

[2] JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROL, BALTIMORE, MD 21205 USA

[3] JOHNS HOPKINS UNIV, SCH MED, DEPT PHYSIOL, BALTIMORE, MD 21205 USA

[4] JOHNS HOPKINS UNIV, SCH MED, DEPT PHARMACOL & MOLEC SCI, BALTIMORE, MD 21205 USA

[5] JOHNS HOPKINS UNIV, SCH MED, DEPT PSYCHIAT & BEHAV SCI, BALTIMORE, MD 21205 USA

来源：

ANNALS OF NEUROLOGY | 1995年 / 37卷 / 01期

关键词：

D O I：

10.1002/ana.410370122

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Gangliosides are polar, sugar-containing lipids that are major constituents of neuronal membranes. Gangliosides are neuroprotective in animal models of neurotoxicity and may also be useful in patients with clinical conditions such as spinal cord injury. We show that a series of gangliosides inhibit nitric oxide synthase activity by binding calmodulin. The prevention of glutamate neurotoxicity in cortical cultures by gangliosides closely parallels their potencies in binding calmodulin and inhibiting nitric oxide synthase. Neuroprotective effects of gangliosides may arise from blockade of nitric oxide formation.

引用

页码：115 / 118

页数：4

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[11] ABUSIVE STIMULATION OF EXCITATORY AMINO-ACID RECEPTORS - A STRATEGY TO LIMIT NEUROTOXICITY [J].