CONSUMPTION OF BRUSSELS-SPROUTS RESULTS IN ELEVATED ALPHA-CLASS GLUTATHIONE-S-TRANSFERASE LEVELS IN HUMAN BLOOD-PLASMA

被引:131
作者
BOGAARDS, JJP [1 ]
VERHAGEN, H [1 ]
WILLEMS, MI [1 ]
VANPOPPEL, G [1 ]
VANBLADEREN, PJ [1 ]
机构
[1] TNO, DEPT HUMAN NUTR, 3700 AJ ZEIST, NETHERLANDS
关键词
D O I
10.1093/carcin/15.5.1073
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The effect of consumption of glucosinolate-containing Brussels sprouts on alpha-class glutathione S-transferase levels in human blood plasma was investigated in 10 healthy, male, nonsmoking volunteers. Following a 3-week run-in period, five volunteers continued on a glucosinolate-free diet during a subsequent 3-week intervention period (control group), while the other five (sprouts group) consumed 300 g of cooked Brussels sprouts per day, at the expense of 300 g of a glucosinolate-free vegetable. alpha-Class glutathione S-transferases were measured by radioimmunoassay. In the control group, similar alpha-class glutathione S-transferase levels were observed in both periods (P = 0.814), while in the sprouts group the alpha-class glutathione S-transferase levels were elevated by a factor of 1.4 (P = 0.002). We hypothesize that the elevated alpha-class GST levels in plasma reflect GST-alpha induction in tissues such as liver and small intestine under non-toxic conditions. The present findings indicate that alpha-class GST levels in plasma may be used as a biomarker for alpha-class GST levels in tissues. In addition, they support the results of epidemiologic studies that consumption of cruciferous vegetables may result in a decreased cancer risk.
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页码:1073 / 1075
页数:3
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