SIMULTANEOUS DETERMINATION OF AMINO-ALPHA-CARBOLINES AND AMINO-GAMMA-CARBOLINES IN CIGARETTE-SMOKE CONDENSATE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：42

作者：

MANABE, S

WADA, O

KANAI, Y

机构：

[1] Department of Hygiene and Preventive Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1990年 / 529卷 / 01期

关键词：

D O I：

10.1016/S0378-4347(00)83813-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A method for the simultaneous detection of amino-α-carbolines (2-amino-α-carboline and 2-amino-3-methyl-α-carboline) and amino-γ-carbolines (3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and 3-amino-1-methyl-5H-pyrido[4,3-b]indole) by high-performance liquid chromatography has been developed. It consists of a three-step purification using three different columns with fluorometric detection. With this method, we have demonstrated that both amino-α-carbolines and amino-γ-carbolines are present in cigarette smoke condensate. The method may be useful for detecting these carcinogens in various materials. © 1990.

引用

页码：125 / 133

页数：9

共 11 条

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