SYNTHESIS OF 2 C-14-LABELED CATECHOL-O-METHYLTRANSFERASE INHIBITORS

被引：3

作者：

KARLSSON, C

HONKANEN, E

机构：

[1] Orion Corporation Ltd, Orion Pharmaceutica, Research Center, Espoo

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1991年 / 29卷 / 02期

关键词：

C-14; LABELING; SYNTHESIS; COMT-INHIBITOR;

D O I：

10.1002/jlcr.2580290214

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

C-14-labelled 3-(3,4-dihydroxy-5-nitrophenylmethylidene)-2,4-pentanedione (4) and C-14-labelled E-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide (5) have been synthesized from [carbonyl-C-14]vanillin.

引用

页码：237 / 239

页数：3

共 3 条

[1] SYNTHESIS OF SOME NOVEL POTENT AND SELECTIVE CATECHOL O-METHYLTRANSFERASE INHIBITORS [J].

BACKSTROM, R ;

HONKANEN, E ;

PIPPURI, A ;

KAIRISALO, P ;

PYSTYNEN, J ;

HEINOLA, K ;

NISSINEN, E ;

LINDEN, IB ;

MANNISTO, PT ;

KAAKKOLA, S ;

POHTO, P .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (04) :841-846

[2] CATECHOL-O-METHYLTRANSFERASE-INHIBITING PYROCATECHOL DERIVATIVES - SYNTHESIS AND STRUCTURE-ACTIVITY STUDIES [J].

BORGULYA, J ;

BRUDERER, H ;

BERNAUER, K ;

ZURCHER, G ;

DAPRADA, M .

HELVETICA CHIMICA ACTA, 1989, 72 (05) :952-968

[3]

PIPPURI A, 1989, Patent No. 89248389

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