PALLADIUM-CATALYZED CROSS-COUPLING REACTION OF ORGANOMETALLOIDS THROUGH ACTIVATION WITH FLUORIDE-ION

被引：264

作者：

HIYAMA, T ^{[1
]}

HATANAKA, Y ^{[1
]}

机构：

[1] SAGAMI CHEM RES CTR,SAGAMIHARA,KANAGAWA 229,JAPAN

来源：

PURE AND APPLIED CHEMISTRY | 1994年 / 66卷 / 07期

关键词：

D O I：

10.1351/pac199466071471

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Activation of organosilicon compounds with fluoride ion produces a transient pentacoordinate silicate, which is capable of transmetalation with a catalytic organopalladium complex and achieves cross-coupling reaction. Mono-, di- or trifluorosilanes can deliver alkenyl, aryl, or alkyl group, respectively. The reaction, characterized by high chemo- and stereoselectivity, was successfully applied to synthesis of HMG-CoA reductase inhibitor NK-104 and functionalized biaryls for liquid crystals. The stereochemical aspects are discussed.

引用

页码：1471 / 1478

页数：8