EVALUATION OF THERAPEUTIC DRUG-MONITORING OF METHOTREXATE IN SALIVA OF CHILDREN WITH RHEUMATIC DISEASES

被引：10

作者：

PRESS, J

BERKOVITCH, M

LAXER, R

GIESBRECHT, E

SILVERMAN, E

KLEIN, J

KOREN, G

机构：

[1] HOSP SICK CHILDREN,DEPT PEDIAT,DIV RHEUMATOL,TORONTO,ON M5G 1X8,CANADA

[2] HOSP SICK CHILDREN,DEPT PEDIAT,DIV CLIN PHARMACOL & TOXICOL,TORONTO,ON M5G 1X8,CANADA

[3] HOSP SICK CHILDREN,DEPT PEDIAT,DIV BIOCHEM,TORONTO,ON M5G 1X8,CANADA

[4] HOSP SICK CHILDREN,INST RES,TORONTO,ON M5G 1X8,CANADA

[5] UNIV TORONTO,DEPT PEDIAT,TORONTO,ON,CANADA

[6] UNIV TORONTO,DEPT PHARMACOL,TORONTO,ON,CANADA

[7] UNIV TORONTO,DEPT PHARMACOL,TORONTO,ON,CANADA

[8] UNIV TORONTO,DEPT PHARM,TORONTO,ON,CANADA

[9] UNIV TORONTO,DEPT MED,TORONTO,ON,CANADA

来源：

THERAPEUTIC DRUG MONITORING | 1995年 / 17卷 / 03期

关键词：

METHOTREXATE; SALIVA SAMPLING; CHILDREN; RHEUMATOLOGICAL DISEASE;

D O I：

10.1097/00007691-199506000-00006

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 [基础医学];

摘要：

Pediatric patients with leukemia, other malignancies, and rheumatological disease receive methotrexate chronically. Because of the documented correlation between methotrexate levels of compliance and clinical outcome, it is conceivable to verify appropriate systemic exposure to the drug. Saliva sampling may be of potential interest, especially in children, in whom blood sampling is ethically limited. Our study shows poor correlation between serum total/free methotrexate concentrations and saliva levels, precluding the clinical use of this test.

引用

页码：247 / 250

页数：4

共 17 条

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[2]

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