VOLTAMMETRIC EVIDENCE THAT SUBSENSITIVITY TO REWARD FOLLOWING CHRONIC MILD STRESS IS ASSOCIATED WITH INCREASED RELEASE OF MESOLIMBIC DOPAMINE

被引:50
作者
STAMFORD, JA
MUSCAT, R
OCONNOR, JJ
PATEL, J
TROUT, SJ
WIECZOREK, WJ
KRUK, ZL
WILLNER, P
机构
[1] CITY LONDON POLYTECH, DEPT PSYCHOL, OLD CASTLE ST, LONDON E1 7NT, ENGLAND
[2] UNIV LONDON, QUEEN MARY & WESTFIELD COLL, DEPT PHARMACOL, LONDON E1 4NS, ENGLAND
基金
英国惠康基金;
关键词
CHRONIC MILD STRESS; SUCROSE REWARD; VOLTAMMETRY; DOPAMINE RELEASE; AUTORECEPTORS; RAT;
D O I
10.1007/BF02244322
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Chronic exposure to mild unpredictable stress caused a decrease in rats' consumption of a palatable weak sucrose solution, which was reversed by chronic (5 weeks) administration of imipramine (5 mg/kg/day). Dopamine (DA) release in the nucleus accumbens (NAc) and caudate putamen (CPu) was measured in vivo using fast cyclic voltammetry, following electrical stimulation of the medial forebrain bundle. Experiments were performed under chloral hydrate anaesthesia 48 h after the termination of stress and the final imipramine injection. DA release was increased in the NAc of both stressed and imipramine-treated animals; imipramine did not normalize the increased DA release in stressed animals. In a further experiment, brain slices from stressed animals tended to be subsensitive to the inhibition of DA release in the NAc by quinpirole. No changes were observed in the CPu in any experiment. We discuss the relationship of these effects to stress-induced anhedonia.
引用
收藏
页码:275 / 282
页数:8
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