ENZYMATIC-PROPERTIES OF THE STONEFISH (SYNANCEIA-VERRUCOSA BLOCH AND SCHNEIDER, 1801) VENOM AND PURIFICATION OF A LETHAL, HYPOTENSIVE AND CYTOLYTIC FACTOR

被引:73
作者
GARNIER, P [1 ]
GOUDEYPERRIERE, F [1 ]
BRETON, P [1 ]
DEWULF, C [1 ]
PETEK, F [1 ]
PERRIERE, C [1 ]
机构
[1] UNIV PARIS SUD, FAC PHARM, BIOL & CONTROLE ORGANISMES PARASITES LAB, EQUIPE TOXINES & INSECTES, F-92290 CHATENAY MALABRY, FRANCE
关键词
D O I
10.1016/0041-0101(94)00151-W
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The crude venom of the stonefish (Synanceia verrucosa) possesses numerous enzymatic properties (hyaluronidase, eight esterases and ten aminopeptidases). Verrucotoxin was isolated by DEAE and hydroxyapatite chromatography, followed by FPLC gel filtration on Superdex 200 HR 10/30. It was found to be a glycoprotein with a mel. wt of 322,000 +/- 2000, comprising four subunits, 2 alpha (83,000) and 2 beta (78,000). Verrucotoxin, as the crude venom, is lethal for mice, haemolyses washed rabbit erythrocytes and induces a fall in arterial pressure in anaesthetized rats.
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页码:143 / 155
页数:13
相关论文
共 58 条
[1]  
AUSTIN L, 1961, ARCH INT PHARMACOD T, V131, P339
[2]   STONEFISH VENOM - SOME BIOCHEMICAL AND CHEMICAL OBSERVATIONS [J].
AUSTIN, L ;
GILLIS, RG ;
YOUATT, G .
AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 1965, 43 :79-+
[3]  
BAGNIS R, 1968, Medecine Tropicale, V28, P612
[4]  
Bloch M.E., 1801, SYSTEMA ICHTHYOLOGIA
[5]  
BOTTARD A, 1889, POISSONS VENIMEUX CO
[6]  
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[8]   SOME PHARMACOLOGICAL PROPERTIES OF VENOM OF SCORPIONFISH SCORPAENA-GUTTATA .2. [J].
CARLSON, RW ;
SCHAEFFE.RC ;
WHIGHAM, H ;
WEIL, MH ;
RUSSELL, FE .
TOXICON, 1972, 11 (02) :167-180
[9]   ISOLATION AND CHARACTERIZATION OF DRACOTOXIN FROM THE VENOM OF THE GREATER WEEVER FISH TRACHINUS-DRACO [J].
CHHATWAL, I ;
DREYER, F .
TOXICON, 1992, 30 (01) :87-93
[10]  
COUTIERE H, 1899, THESIS ECOLE SUP PHA